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VERIFI – PRENATAL TEST

Introduction

It is a test developed by the ILLUMINA laboratory, the WORLD leader in DNA sequencers, they have managed to develop a technology robust enough that the Verifi Prenatal Test is the only test that can report results with less than 4% fraction of fetal DNA (specifically with up to 1.7% fraction of fetal DNA) when the rest of the tests currently work with no less than 4%. The technology used in Verifi is Massively Parallel Sequencing using the latest generation Illumina sequencers; the test in its basic version analyzes chromosomes to report T21, T18, T13, analyzes sex chromosomes to report Turner Syndrome or monosomy X, Klinefelter Syndrome (XXY), Super Male Syndrome (XYYY) and Super Female Syndrome (XXX) and finally reports fetal Sex; This basic version can be performed in twin pregnancies, by IVF and by Ovo donation, however for twin pregnancies only the main trisomies 21, 18 and 13 will be reported and it will report if there is presence or not of the Y chromosome in the sample.

Similarly, we have available the Verifi Plus version that apart from analyzing all the above mentioned in the basic version can report any trisomy that may occur in any of the 23 chromosomes of the fetus, and we add 5 micro deletions that statistically are the most frequent that may occur during pregnancy, such as: Di George Syndrome (22q11. 2), 1p36 deletion syndrome, Wolf-Hirschhorn syndrome (4p), Cri-Du-Chat syndrome (5p) and Prader Willi/Angelman syndrome (15q11.2).

The Verifi test in its two versions has a specificity of 99.9% and a sensitivity of 99.95%, has a very low sample retake rate of about 0.7%, in addition the results reported are in Aneuploidy Detected or Not Detected, Verifi is the only test that reports in its result reports the % of Positive Predictive Value for the cases of aneuploidies detected; for all these added values Verifi Prenatal Test is the best option in non-invasive prenatal testing today.

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Verifi – Prenatal Test

The Verifi Prenatal Test is a non-invasive screening option for chromosomes 21 18, and 13, and fetal sex chromosome aneuploidies in both singleton and twin pregnancies

Highlights:

  • Better than serum screen (fewer false positives)
  •  Fast turnaround time (3-5 days)Low failure rate and high accuracy1

Testing Indications:

  • Advanced maternal age (> 35 years)
  • Positive serum screen
  • Abnormal ultrasoundHistory suggestive of increased risk for the specified chromosome aneuploidies
  • Low-risk/maternal anxiety

Screens for:

  • Trisomy 21 (Down syndrome)
  • Trisomy 18 (Edwards syndrome)Trisomy 13 (Patau syndrome)
  • Fetal sex aneuploidies

Verifi – Plus Prenatal Test

The Verifi Plus Prenatal Test contains everything in the Verifi Prenatal Test and includes additional panels. It is a non-invasive screening option for standard chromosome aneuploidies, certain microdeletions, and all autosomes. Expanded panels (microdeletions or all autosomes) are optional add-ons for singleton pregnancies.

Highlights:

Verifi Plus screens for more chromosome conditions than Verifi.

Testing Indications:

Women who decline an invasive procedure in the presence of an abnormal ultrasound.

Available Optional Add-On Offerings Include:

  • Sex chromosome aneuploidies
    • Monosomy X (MX; Turner syndrome)
    • XXX (Triple X)
    • XXY (Klinefelter syndrome)
    • XYY (Jacobs syndrome)
  • Expanded autosomal trisomies
    • All chromosomes
  • Microdeletion syndromes
    • 1p36 deletion
    • 4p- (Wolf-Hirschhorn syndrome)
    • 5p- (cri-du-chat syndrome)
    • 15q11 (Prader-Willi syndrome/Angelman syndrome)
    • 22q11 deletion (DiGeorge)

Rapid, reliable results.
A one-stop location for testing solutions, in Coconut Creek.